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T₁ estimation for aqueous iron oxide nanoparticle suspensions using a variable flip angle SWIFT sequence.

Luning Wang1, Curtis A Corum, Djaudat Idiyatullin

  • 1Bioimaging Research Center, University of Georgia, Athens, Georgia, USA.

Magnetic Resonance in Medicine
|July 2, 2013
PubMed
Summary

Sweep imaging with Fourier transformation using variable flip angles (VFAs-SWIFT) accurately measures T1 in super-paramagnetic iron oxide nanoparticle suspensions. This method is effective for high concentrations, unlike other techniques.

Keywords:
T1 mappingpositive contrastsuper-paramagnetic iron oxide nanoparticlessweep imaging with Fourier transformation

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Area of Science:

  • Magnetic Resonance Imaging
  • Nanoparticle Contrast Agents
  • Quantitative MRI

Background:

  • T1 quantification of super-paramagnetic iron oxide nanoparticles (SPIONs) is crucial for in vivo MRI applications.
  • Accurate T1 measurements are challenging, especially at higher SPION concentrations.

Purpose of the Study:

  • To propose and evaluate a sweep imaging with Fourier transformation using variable flip angles (VFAs-SWIFT) method for T1 quantification of SPION suspensions.
  • To compare VFA-SWIFT with conventional methods for T1 measurement of SPIONs.

Main Methods:

  • T1 values of aqueous SPION suspensions (1-7 mM) were measured using VFA-SWIFT and 3D spoiled gradient-recalled echo with VFAs (VFA-SPGR) sequences at 7 T.
  • Spectroscopic inversion-recovery sequence on a 7 T spectrometer was used for validation.

Main Results:

  • VFA-SWIFT accurately quantified T1 for SPION suspensions up to 7 mM.
  • VFA-SPGR failed at higher concentrations, while VFA-SWIFT showed its advantage.
  • Both methods yielded linear relaxivity relationships (1.006 and 1.051 s⁻¹ mM⁻¹ at 7 T) in agreement with spectroscopic measurements (1.019 s⁻¹ mM⁻¹).

Conclusions:

  • VFA-SWIFT enables accurate T1 quantification of aqueous SPION suspensions up to 7 mM.
  • The VFA-SWIFT method offers a reliable approach for characterizing SPIONs in MRI.