Related Experiment Video
Updated: Aug 16, 2026
07:25
Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans
Published on: December 9, 2022
[Necrobiosis lipoidica]
J Daróczy1, A Császár, N Hosszúfalusi
1Fövárosi István Kórház-Rendelöintézet Kállai Eva Kórháza, II. Börgyógyászat.
Morphologiai Es Igazsagugyi Orvosi Szemle
|April 1, 1990
Summary
Non-diabetic lipoid necrobiosis involves skin microangiopathy with thickened basal lamina and narrowed veins. Histology reveals a tuberculoid structure and atypical immune globulin synthesis in plasma cells.
Area of Science:
- Dermatopathology
- Histology
- Immunology
Context:
- Investigates the dermal manifestations of non-diabetic lipoid necrobiosis.
- Examines the microvascular and cellular pathology in affected skin tissue.
Purpose:
- To elucidate the microscopic characteristics of skin lesions in non-diabetic lipoid necrobiosis.
- To identify specific histological and ultrastructural features associated with the condition.
Summary:
- Microscopic examination of 8 patients revealed skin microangiopathy, including basal lamina thickening and venous lumen narrowing.
- Histological analysis demonstrated a characteristic tuberculoid structure in dermal symptoms.
- Ultrastructural findings identified orgastoplasmatic corpuscles in plasma cells, suggesting atypical immune globulin synthesis.
Impact:
- Provides detailed histopathological insights into non-diabetic lipoid necrobiosis.
- Contributes to understanding the pathomechanisms, potentially aiding in diagnosis and management.
- Highlights the role of immune dysregulation in the condition's presentation.
Related Concept Videos
01:06Lipid Digestion
Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.
01:30Overview of Cell Death
Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the 20th century...
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the 20th century...
01:18Autophagic Cell Death
Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and pro-apoptotic...
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and pro-apoptotic...
01:16Necrosis
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...
01:24Overview of Lipid Metabolism
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
01:16Cellular Injury IV: Necrosis
Necrosis is a form of irreversible cell death caused by severe injury such as ischemia, toxins, or trauma. Unlike programmed cell death, it is an uncontrolled, pathological process that typically provokes inflammation in surrounding tissues.Pathophysiologic ChangesNecrosis begins when cells sustain critical damage, leading to swelling of organelles, particularly mitochondria, and rapid ATP depletion. As energy levels decline, membrane ion pumps fail, leading to calcium influx and eventually,...