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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Allergic Reactions02:06

Allergic Reactions

Overview
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...

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A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
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Published on: April 13, 2010

Relationship between atopy and bronchial hyperresponsiveness.

Dong In Suh1, Young Yull Koh

  • 1Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.

Allergy, Asthma & Immunology Research
|July 2, 2013
PubMed
Summary

Atopy and bronchial hyperresponsiveness (BHR) are linked in asthma and allergic rhinitis. Understanding this connection in various populations enhances knowledge of airway inflammation and BHR.

Keywords:
Allergic rhinitisasthmaatopybronchial hyperresponsivenesspatientspopulation

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Area of Science:

  • Immunology
  • Pulmonology
  • Allergology

Background:

  • Atopy and bronchial hyperresponsiveness (BHR) are key features of asthma.
  • These conditions also occur in non-asthmatic individuals, such as those with allergic rhinitis and the general population.
  • A strong association exists between atopy and BHR in both asthmatic and non-asthmatic subjects.

Purpose of the Study:

  • To explore the relationship between atopy and BHR.
  • To examine this relationship across different populations: general population, asthmatic subjects, and allergic rhinitis patients.
  • To deepen the understanding of the pathophysiology of atopy and BHR.

Main Methods:

  • Literature review and discussion of existing evidence.
  • Analysis of the role of IgE-mediated allergic responses in airway inflammation.
  • Comparative analysis of atopy and BHR prevalence and correlation in various cohorts.

Main Results:

  • Atopy, characterized by IgE responses to allergens, can induce or exacerbate airway inflammation and BHR.
  • The link between atopy and BHR is evident not only in asthma but also in allergic rhinitis and the general population.
  • Existing evidence supports a significant correlation between atopic status and BHR across diverse groups.

Conclusions:

  • The relationship between atopy and BHR is a crucial factor in airway diseases.
  • Recognizing this link in broader populations offers insights into asthma development and allergic conditions.
  • Further research into the shared pathophysiology can inform diagnostic and therapeutic strategies.