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Breastfeeding Might Have Protective Effects on Atopy in Children With the CD14C-159T CT/CC Genotype

So-Yeon Lee1, Mi-Jin Kang, Ji-Won Kwon

  • 1Department of Pediatrics, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.

Allergy, Asthma & Immunology Research
|July 2, 2013
PubMed

Insights

Breastfeeding may reduce the risk of allergic sensitization in children. This effect is more pronounced in children with specific CD14 gene variations, suggesting a gene-environment interaction.

Area of Science:

  • Immunology
  • Genetics
  • Pediatrics

Background:

  • Breastfeeding is broadly recommended for reducing allergic diseases like asthma and eczema.
  • The precise role of breastfeeding in preventing atopic sensitization remains unclear.
  • Genetic factors may influence the effectiveness of breastfeeding in allergy prevention.

Purpose of the Study:

  • To examine if the CD14 gene influences the association between breastfeeding and aeroallergen sensitization in school children.
  • To investigate the potential gene-environment interaction between CD14 genotype and breastfeeding in the context of atopy.

Main Methods:

  • A cohort of 1,828 school children (aged 9-12) was studied.
  • Data collected via questionnaires, skin prick tests for 12 aeroallergens, and genotyping for the CD14C-159T polymorphism.
  • Statistical analyses, including adjusted odds ratios (aOR) and confidence intervals (CI), were used.

Main Results:

  • Breastfed children showed a reduced likelihood of sensitization to aeroallergens (aOR 0.712, 95% CI: 0.555-0.914).
  • No significant direct association was found between the CD14C-159T genotype and atopy.
  • Breastfeeding was linked to decreased atopic sensitization risk in children with the CT/CC genotype (aOR 0.667, 95% CI: 0.463-0.960).

Conclusions:

  • Breastfeeding is associated with a lower risk of aeroallergen sensitization in school children.
  • A potential gene-environment interaction exists between the CD14C-159T polymorphism and breastfeeding in preventing atopic sensitization.
  • These findings highlight the importance of genetic background in mediating the protective effects of breastfeeding against allergies.

Keywords:
Breastfeedingcluster of differentiation 14 (CD14)gene-environmental interactionsensitization to aeroallergens

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