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Blood Arsenic and Cadmium Concentrations in End-Stage Renal Disease Patients who were on Maintenance Haemodialysis

Subha Palaneeswari M1, P M Abraham Sam Rajan, Santhi Silambanan

  • 1Assistant Professor, Department of Biochemistry, Sree Balaji Medical College and Hospital , Chrompet, Chennai-600 044, India .

Journal of Clinical and Diagnostic Research : JCDR
|July 2, 2013
PubMed

Insights

Blood arsenic and cadmium levels are elevated in end-stage renal disease (ESRD) patients undergoing maintenance hemodialysis (MHD). These levels increase with the duration of MHD, suggesting a link to chronic kidney disease progression.

Area of Science:

  • Nephrology
  • Environmental Health
  • Toxicology

Background:

  • Rising burden of chronic diseases like hypertension and diabetes in India.
  • 25-40% of these patients develop chronic kidney disease (CKD), often requiring renal replacement therapy.
  • Haemodialysis is a common treatment for end-stage renal disease (ESRD).

Purpose of the Study:

  • To investigate blood arsenic and cadmium levels in ESRD patients on maintenance haemodialysis (MHD).
  • To determine if there is a relationship between these element concentrations and the duration of MHD.

Main Methods:

  • Blood samples analyzed from 50 healthy subjects and 50 ESRD patients on MHD.
  • Exclusion of participants with a history of smoking or industrial exposure.

Main Results:

  • Significantly higher blood arsenic and cadmium concentrations in ESRD patients on MHD compared to healthy controls.
  • A positive correlation observed between blood arsenic and cadmium levels and the duration of MHD.

Conclusions:

  • Elevated blood arsenic and cadmium in MHD patients suggest potential environmental exposure.
  • Prolonged exposure, even at low levels, may contribute to renal damage or CKD progression.
  • Further research is warranted to explore the implications of these findings.
Abstract

Keywords:
ArsenicCadmiumEnd-stage renal diseaseMaintenance haemodialysis

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