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The Perforation-Operation time Interval; An Important Mortality Indicator in Peptic Ulcer Perforation

Sushama Surapaneni1, Rajkumar S, Vijaya Bhaskar Reddy A

  • 1Assistant Professor, Department of Surgery.

Journal of Clinical and Diagnostic Research : JCDR
|July 2, 2013
PubMed

Insights

Reducing the time between peptic ulcer perforation and surgery significantly improves patient outcomes. Shorter perforation-operation intervals (POI) are key indicators for lower mortality and morbidity in peritonitis patients.

Area of Science:

  • General Surgery
  • Gastroenterology
  • Surgical Prognosis

Background:

  • Peptic ulcer perforation leading to peritonitis presents a significant clinical challenge.
  • Early prognosis in such cases is crucial for effective patient management.
  • The Perforation-Operation Interval (POI) is a potential factor influencing outcomes.

Purpose of the Study:

  • To determine the prognostic significance of the Perforation-Operation Interval (POI).
  • To assess the impact of POI on mortality and morbidity in patients with peritonitis due to peptic ulcer perforation.

Main Methods:

  • A case series study involving 150 patients diagnosed with Perforated Peptic Ulcers (PPUs) and generalized peritonitis.
  • Diagnosis was based on history, clinical examination, and radiological findings.
  • The Perforation-Operation Interval (POI) was calculated from symptom onset to surgical intervention.

Main Results:

  • The study included 150 patients (134 males, 16 females) aged 25-70 years.
  • 65 patients (43.3%) presented within 24 hours (Group A), 27 (18%) between 24-48 hours (Group B), and 58 (38.6%) after 48 hours (Group C).
  • No mortality occurred in Group A; morbidity increased in Groups B and C, with 15 deaths in Group C.

Conclusions:

  • The Perforation-Operation Interval (POI) is the most critical indicator for mortality and morbidity in peptic ulcer perforation.
  • Decreasing the time from perforation to operation can reduce complications and improve survival rates.
Abstract

Keywords:
Perforated Peptic Ulcer (PPU)Perforation-Operation time Interval (POI)

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