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Cushing Syndrome I: Introduction

Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...
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Related Experiment Video

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The crouzan syndrome-a case report.

Manu Prasad1, Ashwini S Shetty, Manjula Shantaram

  • 1Consultant Surgeon, Department of Craniofacial Surgery, Yenepoya University Hospital, Yenepoya University , Mangalore 575 018, Karnataka, India .

Journal of Clinical and Diagnostic Research : JCDR
|July 2, 2013
PubMed
Summary

Crouzon syndrome, a genetic disorder causing premature cranial suture fusion, presents with distinct facial features and dental issues. This article details a six-year-old girl's case and the necessary multidisciplinary management approach.

Keywords:
Craniofacial syndromesCrouzon syndromePremature synostosis

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Area of Science:

  • Genetics
  • Craniofacial abnormalities
  • Pediatric medicine

Background:

  • Crouzon syndrome is an autosomal dominant genetic disorder.
  • It is characterized by craniosynostosis, leading to premature closure of cranial sutures.
  • Key features include brachycephaly, ocular proptosis, midface hypoplasia, and dental anomalies.

Purpose of the Study:

  • To present a case of Crouzon syndrome in a six-year-old girl.
  • To highlight the characteristic symptoms observed in the case.
  • To emphasize the importance of a multidisciplinary approach in managing Crouzon syndrome.

Main Methods:

  • Case report presentation.
  • Clinical observation of symptoms.
  • Discussion of a multidisciplinary management strategy.

Main Results:

  • The patient exhibited typical Crouzon syndrome features, including craniosynostosis and midface hypoplasia.
  • Dental issues such as hypodontia and crowding were noted.
  • The case underscores the need for comprehensive, team-based care.

Conclusions:

  • Crouzon syndrome requires early diagnosis and a coordinated multidisciplinary approach for optimal outcomes.
  • Management involves addressing craniofacial, dental, and ophthalmological aspects.
  • This case illustrates the practical application of such a management strategy.