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Updated: May 10, 2026

Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension
Published on: March 17, 2022
A rare cause of acute heart failure
Eulália Pereira1, Anabela Vaz, Marta Ponte
1Serviços de Cardiologia e de Cirurgia Cardiotorácica do Centro Hospitalar de Vila Nova de Gaia/ Espinho e Serviço de Medicina Interna do Centro Hospitalar do Nordeste - Portugal.
Abstract:
We describe a rare clinical case of ruptured sinus of Valsalva aneurysm (RSVA) into the right ventricle, complicated with severe aortic regurgitation (AR) and myocardial ischaemia. The AR was caused by a hemodynamic effect solely, in which the shunt of blood flow through the ruptured site pulled the right aortic cusp away from closure. The pathological mechanism of the AR was clearly visualized by transesophageal echocardiography. Early successful primary closure of the RSVA resulted in resolution of the associated AR without any additional procedure.
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