Amyloid precursor proteins are constituents of the presynaptic active zone

Melanie Laßek1, Jens Weingarten, Ulf Einsfelder

  • 1Department of Molecular and Cellular Neurobiology, Goethe-University, Frankfurt am Main, Germany.

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Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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Sorting of outer membrane proteins:
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