Related Experiment Video
Updated: May 10, 2026
12:08
Monitoring the Reductive and Oxidative Half-Reactions of a Flavin-Dependent Monooxygenase using Stopped-Flow Spectrophotometry
Published on: March 18, 2012
Redox pioneer: Professor Stuart A. Lipton.
1Institute for Transformative Molecular Medicine and Harrington Discovery Institute, Case Western Reserve University and University Hospital Case Medical Center, Cleveland, Ohio 44106, USA. jss156@case.edu
Antioxidants & Redox Signaling
|July 3, 2013
Summary
Dr. Lipton
Area of Science:
- Neuroscience
- Biochemistry
- Molecular Biology
Background:
- Pioneering research on S-nitrosylation, a key post-translational modification regulating protein activity.
- Established S-nitrosylation of the NMDA receptor as a model for allosteric control.
- Investigated aberrant protein nitrosylation in neurodegenerative diseases.
Discussion:
- Aberrant protein nitrosylation contributes to Alzheimer's, Parkinson's, Huntington's, and ALS.
- Nitrosative stress, combined with genetic mutations, can trigger disease phenotypes.
- Nitrosative stress arises from specific protein modifications.
Key Insights:
- S-nitrosylation regulates NMDA receptor function.
- Aberrant nitrosylation is implicated in neurodegeneration.
- Targeted S-nitrosylation offers neuroprotection strategies.
Outlook:
- Developing novel neuroprotective drugs targeting the NMDA receptor.
- Understanding the interplay between nitrosative stress and genetic factors in disease.
- Further elucidating the role of S-nitrosylation in neurological disorders.
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