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Updated: May 10, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

The omics in migraine.

Luana Lionetto¹, Giovanna Gentile, Elisa Bellei

¹Sant'Andrea Hospital, Advanced Molecular Diagnostics Unit, Via di Grottarossa 1035 - 1039, Rome 00189, Italy. luanalionetto@gmail.com.

The Journal of Headache and Pain

|July 3, 2013

Summary

Omics synergism, integrating genomics, proteomics, and metabolomics, offers a powerful approach to understanding migraine. Future research should focus on networking these disciplines to unravel migraine's complex molecular biology.

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Area of Science:

Molecular Biology
Systems Biology
Genomics
Proteomics
Metabolomics

Background:

Migraine is a complex, multifactorial neurological disorder.
The integration of 'omics' disciplines provides a holistic view of biological systems.
Understanding the molecular underpinnings of migraine is crucial for developing effective treatments.

Purpose of the Study:

To review and analyze current research data on the role of omics synergism in migraine pathophysiology.
To highlight the importance of integrating genomics, proteomics, and metabolomics for migraine research.
To propose a future direction for migraine biomolecular research focused on interdisciplinary networking.

Main Methods:

Literature review of existing research data.
Analysis of omics data as single or multiple factors in migraine pathophysiology.
Synthesis of findings to illustrate the complex network of migraine molecular biology.

Main Results:

Omics synergism reveals migraine as an ideal model due to its complexity.
Analysis of individual and combined omics data provides insights into migraine's multifactorial nature.
The interconnectedness of different omics disciplines is key to understanding migraine.

Conclusions:

Networking among genomics, proteomics, and metabolomics is essential for advancing migraine research.
A comprehensive understanding of migraine's molecular biology requires an integrated, systems-level approach.
Future research must focus on unraveling the 'Ariadne's tread' within the complex omics network of migraine.