Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Classification of Illness01:17

Classification of Illness

The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sparse Pd-Te Covalent Bridges Drive Anomalous Bulk-to-Monolayer Electronic and Magnetic Evolution in FePd<sub>2</sub>Te<sub>2</sub>.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

SAPCD2 phosphorylation modulates astral microtubule stability to control spindle orientation.

Communications biology·2026
Same author

Open reduction versus closed reduction percutaneous pinning for the treatment of song type V lateral humeral condyle fractures in children. A short term report.

Frontiers in pediatrics·2025
Same author

Nap1L4a Cooperates with Scl/Klf1 to Recruit H2A.Z in Mediating Interactions Among Cis-Regulatory Elements and Transcription Required for Primitive Erythropoiesis in Zebrafish.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same author

Immunotoxicity and effects of gut microbiota in chicks exposed to low doses of deoxynivalenol and 15-acetyl-deoxynivalenol.

Toxicology and applied pharmacology·2025
Same author

Epmedin C Alleviates Deoxynivalenol-Induced Immunotoxicity by Inhibiting Caspase-1 Activation in Chicken Macrophages.

Journal of agricultural and food chemistry·2025

Related Experiment Video

Updated: May 10, 2026

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

Diagnostic prediction of complex diseases using phase-only correlation based on virtual sample template.

Shu-Lin Wang1, Yaping Fang, Jianwen Fang

  • 1Applied Bioinformatics Laboratory, the University of Kansas, 2034 Becker Drive, Lawrence, KS 66047, USA.

BMC Bioinformatics
|July 3, 2013
PubMed
Summary

A novel phase-only correlation (POC) method effectively classifies complex diseases by comparing gene expression patterns. This approach offers robust and accurate diagnosis, outperforming existing machine learning techniques.

More Related Videos

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Standardized SDS-PAGE Workflow for Personalized Protein Corona Profiling in Early Cancer Detection
10:02

Standardized SDS-PAGE Workflow for Personalized Protein Corona Profiling in Early Cancer Detection

Published on: December 19, 2025

Related Experiment Videos

Last Updated: May 10, 2026

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Standardized SDS-PAGE Workflow for Personalized Protein Corona Profiling in Early Cancer Detection
10:02

Standardized SDS-PAGE Workflow for Personalized Protein Corona Profiling in Early Cancer Detection

Published on: December 19, 2025

Area of Science:

  • Bioinformatics
  • Systems Biology
  • Genomics

Background:

  • Complex diseases disrupt biological networks, creating unique equilibrium states.
  • Identifying gene expression patterns aids in diagnosing and treating complex diseases.
  • High dimensionality and small sample sizes challenge current gene expression analysis.

Purpose of the Study:

  • To develop a novel classification method for complex diseases using gene expression data.
  • To address challenges in analyzing high-dimensional, small-sample complex disease datasets.

Main Methods:

  • A phase-only correlation (POC) based classification approach is proposed.
  • Virtual sample templates are created by averaging training data for each disease subclass.
  • Test sample classification is based on similarity measurements to these templates.

Main Results:

  • The POC method accurately recognizes complex disease types.
  • It effectively identifies similarities in overall expression patterns while tolerating minor variations.
  • Experimental validation on seven diverse datasets confirms the method's efficacy.

Conclusions:

  • The POC-based method provides effective and robust diagnosis for complex diseases.
  • Its performance is comparable or superior to state-of-the-art machine learning methods.
  • The method avoids parameter tuning and data scaling, reducing over-fitting and bias.