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Related Concept Videos

Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...

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Related Experiment Video

Updated: May 10, 2026

Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma
12:16

Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma

Published on: March 13, 2013

CD133: a stem cell biomarker and beyond.

Zhong Li1

  • 1Central Laboratory, the 10th People's Hospital, Tongji University, 301 Middle Yanchang Road, Shanghai 200072, China. lizhongsh@yahoo.com.

Experimental Hematology & Oncology
|July 3, 2013
PubMed
Summary
This summary is machine-generated.

Cancer stem cells (CSCs) drive tumor growth and resistance. This review explores the CD133 biomarker

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Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting
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Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting

Published on: June 18, 2018

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors
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Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors

Published on: March 1, 2020

Related Experiment Videos

Last Updated: May 10, 2026

Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma
12:16

Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma

Published on: March 13, 2013

Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting
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Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting

Published on: June 18, 2018

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors
07:01

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors

Published on: March 1, 2020

Area of Science:

  • Oncology
  • Cell Biology
  • Biochemistry

Background:

  • Cancer stem cells (CSCs) are implicated in tumor initiation, metastasis, recurrence, and chemoresistance.
  • CD133, a cell surface glycoprotein, has been utilized as a biomarker for CSC identification since 1999.
  • Emerging research highlights the functional significance of CD133 in cancer biology.

Purpose of the Study:

  • To review recent advancements in understanding CD133 regulation.
  • To elucidate the multifaceted roles of CD133 in CSCs.
  • To consolidate knowledge on CD133's involvement in key cancer processes.

Main Methods:

  • Literature review of recent studies on CD133.
  • Synthesis of data on CD133's regulatory mechanisms.
  • Analysis of CD133's functional implications in cancer.

Main Results:

  • CD133 plays a critical role in regulating CSC self-renewal and differentiation.
  • CD133 is involved in tumor initiation, metastasis, and resistance to therapy.
  • CD133 influences cancer cell metabolism, autophagy, apoptosis, and regeneration.

Conclusions:

  • CD133 is a key regulator of CSC functions and a potential therapeutic target.
  • Understanding CD133's complex roles is crucial for developing effective cancer treatments.
  • Further research into CD133 regulation and function will advance cancer stem cell biology.