Related Experiment Video
Updated: May 10, 2026

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
Published on: August 23, 2019
Essential genes in thyroid cancers: focus on fascin
Hilda Samimi1, Majid Zaki Dizaji, Mohsen Ghadami
1Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, 5th floor, Dr, Shariati Hospital, North Kargar Ave, Tehran, Iran. v.haghpanah@gmail.com.
Thyroid cancers progress through sequential genetic events, involving key genes like P53 and RAS. This review highlights the role of epithelial mesenchymal transition and Fascin in thyroid tumor formation.
Area of Science:
- Endocrinology
- Oncology
- Molecular Biology
Background:
- Thyroid cancer is the most common endocrine malignancy.
- Tumorigenesis involves sequential genetic alterations.
- Key genes implicated include proto-oncogenes, transcription factors, and metastasis elements.
Purpose of the Study:
- To review essential genes in thyroid cancer development.
- To highlight the role of epithelial mesenchymal transition (EMT).
- To emphasize the significance of Fascin in thyroid tumorigenesis.
Main Methods:
- Literature review of published studies.
- Analysis of genetic events in thyroid cancer progression.
- Focus on specific genes: P53, RAS, RET, BRAF, PPARγ, and Fascin.
Main Results:
- Thyroid cancer progression is driven by accumulated genetic mutations and rearrangements.
- Specific genes (P53, RAS, RET, BRAF, PPARγ) are crucial in neoplastic transformation.
- Epithelial mesenchymal transition (EMT) and the Fascin protein play significant roles.
Conclusions:
- Understanding genetic events is key to comprehending thyroid cancer.
- EMT and Fascin are critical factors in thyroid cancer progression and metastasis.
- Further research into these genetic elements can inform therapeutic strategies.
Related Concept Videos
Synthesis and Regulation of Thyroid Hormones
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...
Cancer-Critical Genes I: Proto-oncogenes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes I: Proto-oncogenes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Mitogens and the Cell Cycle
Cadherins in Tissue Organization
Cell Sorting During Development
Cell sorting plays an...
Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

