A multi-site feasibility study for personalized medicine in canines with osteosarcoma

Area of Science:

• Veterinary oncology
• Genomics
• Personalized medicine

Background:

• Personalized medicine aims to tailor treatments to individual patients and their diseases.
• Canine osteosarcoma presents a challenge for developing targeted therapeutic strategies.

Purpose of the Study:

• To assess the feasibility of a gene expression-based Personalized Medicine (PMed) approach for canine osteosarcoma.
• To refine the infrastructure and processes for prospective clinical trials within a 5-day turnaround time.

Main Methods:

• Tumor samples from canine osteosarcoma patients were collected and processed for RNA extraction and pathological diagnosis.
• Genomic profiling was performed, and gene expression data were analyzed using PMed algorithms.
• Turnaround time for PMed report generation and veterinarian feedback were recorded.

Main Results:

• 13 out of 20 enrolled subjects had samples pass quality control for genomic analysis.
• PMed reports were generated and communicated to veterinarians for 11 of these 13 samples within the 5-business-day target.
• Veterinarian feedback indicated a need for improved education, drug availability, pricing, and dosing information.

Conclusions:

• A 5-day turnaround for molecular tumor analysis and therapeutic decision support is feasible with established infrastructure.
• Improvements in sample quality control and veterinarian support are necessary for broader clinical application.
• This study provides a foundation for prospective clinical trials in canine osteosarcoma utilizing personalized medicine.