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Friction-induced pagetoid dyskeratosis
Faisal Al-Mohammedi1, Gillian C de Gannes, Richard I Crawford
1Department pf Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC.
Journal of Cutaneous Medicine and Surgery
|July 3, 2013
Summary
Pagetoid dyskeratosis (PD) is a skin condition often found incidentally. This study confirms friction as a direct cause of PD, observed in a biopsy immediately after lesion induction.
Area of Science:
- Dermatology
- Histopathology
Background:
- Pagetoid dyskeratosis (PD) presents as pale epidermal cells, mimicking Paget disease.
- It's an incidental finding in benign papules, typically in intertriginous areas.
- PD is considered a reactive keratinocyte alteration, with friction previously suggested as a trigger.
Observation:
- A 19-year-old woman presented with clinically induced bullae and erosions.
- A biopsy was performed immediately after artificial lesion induction.
- The biopsy revealed combined features of PD and friction bulla.
Findings:
- Direct cause-and-effect relationship between friction and Pagetoid dyskeratosis confirmed.
- Histopathological evidence demonstrates friction-induced changes consistent with PD.
- This finding supports friction as an etiological factor for PD.
Implications:
- Establishes friction as a causative agent for Pagetoid dyskeratosis.
- Provides crucial histopathological evidence for understanding reactive epidermal changes.
- Informs differential diagnosis and management of friction-induced skin lesions.
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