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Redo aortic valve replacement in a patient with immunoglobulin A deficiency and hemophilia A

Michael G Fitzsimons1, Ken Walton, Robert Makar

  • 1Division of Cardiac Anesthesia, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. mfitzsimons@partners.org

The Annals of Thoracic Surgery
|July 3, 2013
PubMed

Immunoglobulin A (IgA) deficiency may result in the development of anti-IgA antibodies. Such antibodies may result in anaphylaxis when patients receive standard blood products. Hemophilia A is a deficiency of clotting factor VIII that results in a significant coagulopathy and bleeding in the perioperative period unless precautions are taken. We present a case of successful management of combined hemophilia A and IgA deficiency in a patient undergoing repeated sternotomy for aortic valve replacement.

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