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A Modified Method for Intrathecal Catheterization in Rats
Published on: February 14, 2025
Advances in intrathecal drug delivery
Jose De Andres1, Juan M Asensio-Samper, Gustavo Fabregat-Cid
1aDepartment of Surgical Specialties, Anesthesia Division, Valencia University Medical School bAnesthesia Department cMultidisciplinary Pain Management Department, Valencia General University Hospital, Valencia, Spain.
Purpose Of Review:
Targeted intrathecal drug delivery systems (IDDS) are an option in algorithms for the treatment of patients with moderate-to-severe chronic refractory pain. This article is intended to review the literature regarding IDDS published over the last year, with special attention to the Polyanalgesic Consensus Conference 2012.
Recent Findings:
The recommendations made by the Polyanalgesic Consensus Conference 2012 are reviewed. Separate considerations of intrathecal drug therapy for neuropathic and nociceptive pain syndromes and the new concept of 'microdosing' are discussed in this article.
Summary:
This review includes the recommendations for the use of IDDS, trialing, and recent reports of complications (especially, the occurrence of granulomas). In addition, the latest documents on cerebrospinal fluid and potential lines of future development are discussed.
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