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Related Experiment Video

Updated: May 10, 2026

Detection and Removal of Tooth-Colored Composite Resin Using the Fluorescence-Aided Identification Technique

Detection and Removal of Tooth-Colored Composite Resin Using the Fluorescence-Aided Identification Technique

Published on: July 27, 2022

Fluorides and non-fluoride remineralization systems.

Bennett T Amaechi¹, Cor van Loveren

¹Department of Comprehensive Dentistry, University of Texas Health Science Center at San Antonio, San Antonio, Tex., USA.

Monographs in Oral Science

|July 3, 2013

Summary

Fluoride toothpastes effectively prevent cavities by promoting tooth remineralization. However, evidence for other remineralization systems is less convincing, with a lack of direct comparisons.

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Last Updated: May 10, 2026

Detection and Removal of Tooth-Colored Composite Resin Using the Fluorescence-Aided Identification Technique

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Published on: July 27, 2022

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Published on: March 31, 2021

Area of Science:

Dentistry
Biomineralization
Materials Science

Background:

Dental caries results from an imbalance favoring demineralization over remineralization.
Tooth mineral remineralization depends on interstitial fluid saturation with calcium and phosphate ions.
Fluoride enhances remineralization and forms less soluble mineral structures.

Purpose of the Study:

To review the effectiveness of different remineralization systems in toothpastes.
To assess the clinical evidence supporting fluoride and other remineralization agents.
To identify gaps in the evidence regarding comparative effectiveness.

Main Methods:

Literature review of clinical evidence for various toothpaste remineralization systems.
Analysis of the chemical interactions and formulation challenges of calcium and fluoride compounds.
Assessment of the strength of evidence for caries prevention.

Main Results:

Strong clinical evidence supports the caries preventive effects of fluoride toothpastes.
Evidence for the effectiveness of other remineralization systems is less convincing.
There is a significant lack of head-to-head clinical comparisons between different remineralization systems.

Conclusions:

Fluoride remains the gold standard for caries prevention in toothpastes.
Further research is needed to validate the efficacy of alternative remineralization systems.
Comparative studies are essential to guide product development and clinical recommendations.