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Disorders of Hemostasis

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Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
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Disorders of Erythrocytes

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Hemorrhagic Stroke ll: Pathophysiology

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Blood Pressure Imbalances and Circulatory Shock

Blood Pressure Imbalances and Circulatory Shock

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Extrinsic and Intrinsic Pathways of Hemostasis

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Related Experiment Video

Updated: May 10, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Hemostatic abnormalities in sickle cell disease.

Ming Y Lim¹, Kenneth I Ataga, Nigel S Key

¹Division of Hematology/Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

Current Opinion in Hematology

|July 3, 2013

Summary

This summary is machine-generated.

Sickle cell disease (SCD) increases the risk of venous thromboembolism (VTE) due to chronic hypercoagulation. Hemolysis and blood cells play a key role in this thrombophilic state, requiring further study for effective therapies.

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Published on: November 5, 2019

Area of Science:

Hematology
Vascular Biology
Thrombosis Research

Background:

Sickle cell disease (SCD) is linked to chronic hypercoagulation.
Venous thromboembolism (VTE) complications in SCD are increasingly recognized.
Hemolysis is implicated in the hypercoagulable state of SCD.

Purpose of the Study:

To review the evolving epidemiology of VTE in SCD.
To explore the mechanistic role of hemolysis in SCD-associated hypercoagulation.
To understand the complex pathways underlying the thrombophilic state in SCD.

Main Methods:

Review of recent literature on SCD and VTE.
Utilized global coagulation assays (thromboelastography, thrombin generation assays).
Analysis of mechanistic studies in human and mouse models.

Main Results:

Recent literature strengthens the evidence for SCD as a thrombophilic state.
Global coagulation assays suggest a role for peripheral blood cells and microparticles.
Inconsistent results from global assays may be due to technical differences.

Conclusions:

VTE is an underappreciated complication of SCD.
The hypercoagulable state in SCD is complex and multifactorial.
Understanding these mechanisms may guide novel antithrombotic therapies for SCD.