Related Experiment Video
Updated: May 10, 2026
05:57
Establishment and Histological Analysis of Esophageal Organoids Modeling the Progression from Normal to Cancerous Tissues
Published on: May 30, 2025
Neurogenous hyperplasia in the oesophagus
1Department of Pathology, Mersin University, Mersin, Turkey. karabacaktuba@hotmail.com
The Malaysian Journal of Pathology
|July 3, 2013
Summary
Neurogenous hyperplasia, a condition previously unreported in the esophagus, was identified in a patient. This finding suggests neurogenous hyperplasia may occur in the esophagus, similar to its presence in the appendix.
Area of Science:
- Gastroenterology and Pathology
Background:
- Mesenchymal tumors of the esophagus are typically leiomyomas or gastrointestinal stromal tumors.
- Tumors of peripheral nerve origin are rare in the esophagus.
- Neurogenous hyperplasia, characterized by Schwann and enterochromaffin cell proliferation, is documented in the appendix but not previously reported in the esophagus.
Observation:
- A 58-year-old woman presented with linear erosions and nodularity at the gastroesophageal junction.
- Endoscopic biopsies revealed a proliferation of spindle cells in the lamina propria.
- Microscopic examination showed cells with oval-round nuclei in a focal fascicular arrangement.
Findings:
- Immunohistochemistry confirmed the spindle cells stained positive for synaptophysin and S100-protein.
- Immunohistochemistry results for smooth muscle actin and CD117 were negative.
- The findings led to a diagnosis of neurogenous hyperplasia.
Implications:
- This case report suggests neurogenous hyperplasia is a distinct entity that can occur in the esophagus.
- The findings expand the known anatomical distribution of neurogenous hyperplasia.
- Further research is warranted to understand the incidence and clinical significance of esophageal neurogenous hyperplasia.
Related Concept Videos
01:27Esophageal Achalasia
Esophageal achalasia is a chronic neurogenic disorder characterized by impaired relaxation of the lower esophageal sphincter (LES) and absent or ineffective peristalsis in the distal esophagus. This leads to a functional obstruction without a physical blockage, despite significant disruption of esophageal motility.EtiologyAchalasia is caused by degeneration of the myenteric (Auerbach's) plexus, specifically the loss of inhibitory ganglion cells that produce vasoactive intestinal peptide (VIP)...
01:26Cellular Adaptation III: Hyperplasia
Hyperplasia is an increase in the number of cells in a tissue or organ due to enhanced cell division. It is an adaptive, controlled response to stimuli such as injury, hormones, or stress, involving mitosis to produce genetically identical cells and support tissue repair and regeneration.Tissue CapacityCertain tissues, including the epidermis, intestinal epithelium, bone marrow, and fibroblasts, have a high potential for hyperplasia. Others, such as bone, cartilage, and smooth muscle, show...
01:21Barrett Esophagus-I: Introduction
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more similar...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more similar...
01:24Cellular Adaptation IV: Dysplasia and Metaplasia
DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...
01:30Esophageal Strictures-I: Introduction
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
01:25Gastroesophageal Reflux Disease
Gastroesophageal reflux disease (GERD) is the backward flow of stomach contents (acid, pepsin, or bile) into the esophagus, causing mucosal inflammation known as esophagitis. It results from failure of antireflux mechanisms, mainly the lower esophageal sphincter (LES), influenced by mechanical and physiological factors.Etiology and Risk FactorsGERD develops when LES function is weakened or when intra-abdominal pressure increases. Risk factors include aging, obesity, and sliding hiatal hernia,...