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Related Experiment Video

Updated: May 10, 2026

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

Sorafenib and thyroid cancer.

Poupak Fallahi¹, Silvia Martina Ferrari, Francesca Santini

¹Department of Clinical and Experimental Medicine, University of Pisa, Via Savi, 10, 56126, Pisa, Italy.

Biodrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy

|July 3, 2013

Summary

Sorafenib, a multikinase inhibitor, shows promise for advanced thyroid cancer. Clinical trials indicate its effectiveness in treating aggressive, unresponsive thyroid cancer cases.

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Published on: June 2, 2023

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Last Updated: May 10, 2026

Spontaneous Murine Model of Anaplastic Thyroid Cancer

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Published on: February 3, 2023

Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma

Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma

Published on: June 2, 2023

Area of Science:

Oncology
Pharmacology

Background:

Sorafenib is a multikinase inhibitor with anti-proliferative and anti-angiogenic properties.
It targets key pathways in tumor cells and vasculature, including c-RAF, BRAF, and VEGFR.

Purpose of the Study:

To review the anti-neoplastic effects of sorafenib in thyroid cancer.
To summarize findings from clinical trials on sorafenib for advanced thyroid cancer.

Main Methods:

Review of completed and ongoing clinical studies.
Evaluation of sorafenib's efficacy and tolerability in thyroid cancer patients.

Main Results:

Sorafenib has demonstrated effectiveness in advanced thyroid cancer, including anaplastic, papillary, and medullary types.
Studies suggest positive outcomes in patients unresponsive to traditional therapies.

Conclusions:

Sorafenib is a promising therapeutic option for advanced thyroid cancer.
Ongoing evaluations focus on long-term efficacy and safety.