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CHD@ZJU: a knowledgebase providing network-based research platform on coronary heart disease
Leihong Wu1, Xiang Li, Jihong Yang
1Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Summary
This study introduces CHD@ZJU, a new knowledgebase detailing coronary heart disease (CHD) genes, pathways, and drugs. It offers novel insights into CHD molecular mechanisms and aids multi-target therapeutic discovery.
Area of Science:
- Genomics
- Bioinformatics
- Cardiovascular Research
Background:
- Coronary heart disease (CHD) is a major global health burden, linked to numerous genes.
- Understanding these genes and their interactions is crucial for advancing CHD translational research.
Purpose of the Study:
- To construct CHD@ZJU, a comprehensive knowledgebase for CHD-related genes, pathways, drugs, and references.
- To provide a resource for dissecting CHD molecular mechanisms and facilitating multi-target therapeutic discovery.
Main Methods:
- Data collection from diverse resources and text-mining.
- Manual confirmation of CHD-related information.
- Integration of protein-protein interactions for network analysis.
Main Results:
- CHD@ZJU contains 660 CHD-related genes, 45 pathways, and 1405 drugs with over 8000 references.
- Nearly half of the genes in CHD@ZJU are novel compared to existing databases.
- Incorporated protein-protein interactions for multi-layer network analysis.
Conclusions:
- CHD@ZJU serves as a valuable resource for CHD research.
- The knowledgebase facilitates systematic dissection of CHD molecular mechanisms.
- It supports the discovery of novel multi-target therapies for coronary heart disease.
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