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Association between serum interleukin-6 concentration and mortality in patients with coronary artery disease

Dongfang Su1, Zhongxia Li, Xinrui Li

  • 1Guangdong Provincial Key Laboratory of Food, Nutrition, and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China.

Mediators of Inflammation
|July 3, 2013
PubMed

Insights

Elevated serum interleukin-6 (IL-6) levels significantly increase mortality risk in coronary artery disease (CAD) patients. This finding highlights IL-6 as a potential biomarker for cardiovascular disease prognosis.

Area of Science:

  • Cardiovascular Medicine
  • Biomarkers
  • Inflammation Research

Background:

  • Coronary artery disease (CAD) poses a significant global health burden.
  • Inflammatory markers, such as interleukin-6 (IL-6), are increasingly recognized for their role in cardiovascular pathophysiology.
  • Understanding the prognostic value of IL-6 in CAD patients is crucial for risk stratification.

Purpose of the Study:

  • To investigate the association between serum interleukin-6 (IL-6) levels and the risk of all-cause and cardiovascular mortality in patients with coronary artery disease (CAD).

Main Methods:

  • A prospective cohort study was conducted with 718 CAD patients from the Guangzhou Cardiovascular Disease Cohort (GCDC).
  • Multivariable-adjusted Cox proportional hazards regression analyses were employed to assess the relationship between serum IL-6 and mortality outcomes.
  • Follow-up data were collected over 1663 person-years.

Main Results:

  • A one-standard deviation increase in log-transformed serum IL-6 was associated with significantly increased risks of all-cause (HR 2.93) and cardiovascular mortality (HR 2.04).
  • Patients in the highest serum IL-6 tertile exhibited substantially higher risks for all-cause (HR 17.12) and cardiovascular mortality (HR 8.68) compared to the lowest tertile.
  • These associations remained significant after multivariable adjustment, particularly in male patients.

Conclusions:

  • Serum interleukin-6 (IL-6) is a significant independent predictor of both all-cause and cardiovascular mortality in hospitalized patients with coronary artery disease (CAD).
  • IL-6 may serve as a valuable prognostic biomarker for identifying high-risk CAD patients.
Abstract

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