Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Pedigree Analysis01:35

Pedigree Analysis

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of relative handgrip strength and back muscle strength on the incidence of hypertension: 18-year follow-up in a population-based cohort study.

Journal of human hypertension·2026
Same author

Corrigendum to "Artificial intelligence in sleep medicine I: Diagnosis, treatment, care, and research" [Sleep Med Rev 88 (2026) 102295].

Sleep medicine reviews·2026
Same author

Artificial intelligence in sleep medicine I: Diagnosis, treatment, care, and research.

Sleep medicine reviews·2026
Same author

Brain Health from Sleep EEG: A Multicohort, Deep Learning Biomarker for Cognition, Disease, and Mortality.

NEJM AI·2026
Same author

COMPREHENSIVE GENETIC INVESTIGATION REVEALS HETEROGENEOUS PATHWAYS TO OBSTRUCTIVE SLEEP APNEA.

medRxiv : the preprint server for health sciences·2026
Same author

Chemically Defined, Efficient Megakaryocyte Production from Human Pluripotent Stem Cells.

Cells·2025
Same journal

Integrated transcriptomic and metabolomic analysis identifies a core gene-metabolite network linking lysine degradation and propanoate metabolism to psoriasis pathogenesis.

BMC medical genomics·2026
Same journal

Whole exome sequencing uncovers genetic syndromes and putative candidate genes underlying orofacial clefts presenting with limb abnormalities in a Sub-Saharan African cohort.

BMC medical genomics·2026
Same journal

Construction and validation of a lncRNA/circRNA-miRNA-mRNA ceRNA network in allergic rhinitis pathogenesis.

BMC medical genomics·2026
Same journal

Genetic architecture of patients with autism spectrum disorder - data analysis based on the literature review.

BMC medical genomics·2026
Same journal

Elective genomic sequencing for adults in research, clinical and commercial contexts.

BMC medical genomics·2026
Same journal

Targeting acetylcholine: a novel strategy for treating lung adenocarcinoma.

BMC medical genomics·2026
See all related articles

Related Experiment Video

Updated: May 10, 2026

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization
13:55

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization

Published on: February 3, 2013

Diplotyper: diplotype-based association analysis.

Sunshin Kim1, KyungChae Park, Chol Shin

  • 1Department of Biomedical Science, College of Life Science, CHA University, Seongnam, Korea.

BMC Medical Genomics
|July 4, 2013
PubMed
Summary
This summary is machine-generated.

Diplotyper combines haplotype clustering and diplotype trend regression for enhanced genetic association analysis. This novel tool improves the precision of identifying genetic signals, outperforming traditional single-locus tests.

More Related Videos

Infinium Assay for Large-scale SNP Genotyping Applications
13:33

Infinium Assay for Large-scale SNP Genotyping Applications

Published on: November 19, 2013

Digital Polymerase Chain Reaction Assay for the Genetic Variation in a Sporadic Familial Adenomatous Polyposis Patient Using the Chip-in-a-tube Format
05:58

Digital Polymerase Chain Reaction Assay for the Genetic Variation in a Sporadic Familial Adenomatous Polyposis Patient Using the Chip-in-a-tube Format

Published on: August 20, 2018

Related Experiment Videos

Last Updated: May 10, 2026

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization
13:55

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization

Published on: February 3, 2013

Infinium Assay for Large-scale SNP Genotyping Applications
13:33

Infinium Assay for Large-scale SNP Genotyping Applications

Published on: November 19, 2013

Digital Polymerase Chain Reaction Assay for the Genetic Variation in a Sporadic Familial Adenomatous Polyposis Patient Using the Chip-in-a-tube Format
05:58

Digital Polymerase Chain Reaction Assay for the Genetic Variation in a Sporadic Familial Adenomatous Polyposis Patient Using the Chip-in-a-tube Format

Published on: August 20, 2018

Area of Science:

  • Genetics
  • Bioinformatics
  • Statistical genetics

Background:

  • Haplotype cluster analysis and diplotype trend regression are powerful genetic association methods.
  • Existing methods have limitations in combining these approaches for comprehensive analysis.

Purpose of the Study:

  • To introduce Diplotyper, a novel algorithm integrating haplotype cluster- and diplotype-based association analyses.
  • To provide an automated tool for advanced genetic association studies.

Main Methods:

  • Diplotyper integrates a novel haplotype clustering algorithm with established tools (Haploview, PLINK).
  • It generates diplotypes from clusters and transforms them for regression analyses.
  • The tool automates the process of diplotype generation and association testing.

Main Results:

  • Diplotyper is a fully automated tool for population-based diplotype association analysis.
  • The tool was validated using polymorphisms in the hepatic lipase (LIPC) gene and high-density lipoprotein (HDL) cholesterol levels.

Conclusions:

  • Diplotyper enables the identification of more precise and distinct genetic signals compared to single-locus tests.
  • The tool enhances the power of genetic association studies by leveraging diplotype information.