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Postoperative differences between colonization and infection after pediatric cardiac surgery-a propensity matched
Daniel J Lex1, Roland Tóth, Zsuzsanna Cserép
1School of PhD Studies, Semmelweis University, Budapest, Hungary.
Journal of Cardiothoracic Surgery
|July 4, 2013
Summary
Postoperative infection risk factors in pediatric cardiac surgery patients were identified. Positive Staphylococcus aureus cultures and elevated C-reactive protein levels indicate a higher risk of infection conversion from colonization.
Area of Science:
- Pediatric cardiac surgery
- Infectious disease epidemiology
- Critical care medicine
Background:
- Pediatric cardiac surgery patients are susceptible to postoperative infections.
- Understanding the transition from colonization to infection is crucial for patient outcomes.
Purpose of the Study:
- To identify risk factors for the conversion of colonization to infection in pediatric cardiac surgery patients.
- To compare characteristics of patients with infection versus those with only positive cultures.
Main Methods:
- Retrospective analysis of 1665 pediatric cardiac surgery patients (2004-2008).
- Propensity score matching used to compare 141 infected patients with 141 colonized patients.
- Data included demographics, comorbidities, surgery details, lab results, and microbial data.
Main Results:
- 179 patients (9.3%) developed infection; 253 (15.2%) had colonization.
- Gram-positive species were more common in the colonization group.
- Higher C-reactive protein levels (postoperative days 1 & 2) and longer intensive care unit stays were observed in the infection group.
Conclusions:
- Positive Staphylococcus aureus and bloodstream results are independent risk factors for infection.
- Significant differences in postoperative C-reactive protein and white blood cell counts exist between infected and colonized patients.
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