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A Murine Model of Group B Streptococcus Vaginal Colonization
Published on: November 16, 2016
Outbreak of Group A beta hemolytic Streptococcus pharyngitis in a Peruvian military facility, April 2012
Mariana Ramos1, Ruben Valle, Eric J Reaves
1Emerging Infections Department, U.S. Naval Medical Research Unit No. 6, Lima, Peru.
Insights
A large Group A Streptococcus (GAS) outbreak occurred at a Peruvian military facility, infecting 383 trainees. The investigation highlighted challenges in closed populations and identified a rare GAS emm type 80.1 pathogen.
Area of Science:
- Epidemiology
- Infectious Disease Control
- Public Health
Background:
- Group A Streptococcus (GAS) causes pharyngitis and outbreaks in crowded settings.
- Military training facilities are susceptible to GAS transmission due to close living quarters.
Purpose of the Study:
- To investigate a large GAS pharyngitis outbreak at a Peruvian military training facility.
- To understand transmission dynamics and identify the causative agent in a closed population.
Main Methods:
- Retrospective case finding and an anonymous survey of trainees.
- Epidemic curve analysis to determine transmission patterns.
- Laboratory identification of the GAS emm type.
Main Results:
- At least 383 cases of pharyngitis were identified among 1,137 respondents, with a 34% attack rate.
- Epidemic curve suggested person-to-person transmission, with a possible initial event.
- GAS emm type 80.1, uncommon in the Americas, was identified as the pathogen.
Conclusions:
- The study details a significant GAS outbreak in a military population, emphasizing challenges in outbreak detection.
- The identification of emm type 80.1 provides insights into GAS epidemiology.
- Findings underscore the importance of surveillance and control measures in closed environments.
Abstract:
Group A Streptococcus (GAS), or Streptococcus pyogenes, is a common cause of acute pharyngitis as well as other diseases. Closed populations such as those living on military bases, nursing homes, and prisons are particularly vulnerable to GAS outbreaks due to crowding that facilitates person-to-person transmission. This report details a large outbreak of GAS pharyngitis at a Peruvian military training facility near Lima, Peru, in April 2012. Initial findings showed 145 cases. However, as the investigation continued it was revealed that some trainees may have concealed their illness to avoid real or perceived negative consequences of seeking medical care. A subsequent anonymous survey of all trainees revealed at least 383 cases of pharyngitis among the facility's 1,549 trainees and an attack rate of 34 percent among the 1,137 respondents. The epidemic curve revealed a pattern consistent with routine person-to-person transmission, although a point-source initiating event could not be excluded. Laboratory results showed GAS emm type 80.1 to be the culprit pathogen, an organism not commonly implicated in outbreaks of GAS in the Americas. Barious unique and illustrative features of outbreak investigation in military facilities and populations are discussed.
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