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The relationship between neutrophil-to-lymphocyte ratio and vascular calcification in end-stage renal disease

Kultigin Turkmen1, Fatih Ozcicek, Adalet Ozcicek

  • 1Department of Nephrology, Erzincan University Mengucek Gazi Training and Reseach Hospital, Erzincan, Turkey.

Hemodialysis International. International Symposium on Home Hemodialysis
|July 4, 2013
PubMed

Insights

The neutrophil-to-lymphocyte ratio (NLR) correlates with vascular calcification in end-stage renal disease (ESRD) patients. This simple blood marker may help predict coronary artery calcification (CAC) and thoracic aorta calcification (TAC) in ESRD.

Area of Science:

  • Nephrology
  • Cardiology
  • Inflammation Research

Background:

  • Chronic inflammation is linked to coronary artery calcification (CAC) and thoracic aorta calcification (TAC) in end-stage renal disease (ESRD) patients.
  • The neutrophil-to-lymphocyte ratio (NLR) is a potential inflammation marker, but its association with vascular calcification in ESRD is not well-established.

Purpose of the Study:

  • To investigate the relationship between NLR and vascular calcification (TAC and CAC) in patients with ESRD.
  • To determine if NLR can serve as a predictor of vascular calcification in this population.

Main Methods:

  • A cross-sectional study of 56 ESRD patients undergoing dialysis.
  • Coronary artery calcification (CAC) and thoracic aorta calcification (TAC) scores were measured using computed tomography.
  • Neutrophil-to-lymphocyte ratio (NLR) was calculated from blood samples.

Main Results:

  • A significant positive correlation was found between NLR and both TAC (r=0.43, P=0.001) and CAC (r=0.30, P=0.02) in ESRD patients.
  • NLR and age were identified as independent predictors of TAC.
  • Age was the sole independent predictor of CAC.

Conclusions:

  • The neutrophil-to-lymphocyte ratio (NLR) is significantly correlated with vascular calcification in ESRD patients.
  • NLR is a potential, easily calculable marker for predicting vascular calcification, specifically TAC, in ESRD.
  • Further research may explore NLR's utility in managing cardiovascular risk in ESRD patients.

Keywords:
End-stage renal diseasecoronary artery calcification neutrophil-to-lymphocyte ratiothoracic peri-aortic calcification

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