Related Experiment Video

Updated: May 10, 2026

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
09:36

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers

Published on: July 28, 2022

Growth of healthy term infants fed an extensively hydrolyzed casein-based or free amino acid-based infant formula: a

Marlene W Borschel1, Ekhard E Ziegler, Rita Thomas Wedig

  • 11Abbott Nutrition, Abbott Laboratories, Columbus, OH, USA.

Clinical Pediatrics
|July 4, 2013
PubMed

Insights

Amino acid-based formula (AF) supports infant growth comparable to extensively hydrolyzed formula (HF). Both formulas demonstrated similar growth outcomes and serum albumin levels in infants during the first 4 months of life.

Area of Science:

  • Pediatric Nutrition
  • Infant Formula Research
  • Clinical Growth Studies

Background:

  • Infant feeding choices impact growth and development.
  • Hydrolyzed formulas are used for infants with cow's milk allergy.
  • Amino acid-based formulas offer an alternative hypoallergenic option.

Purpose of the Study:

  • To compare growth and tolerance of amino acid-based formula (AF) versus extensively hydrolyzed casein-based formula (HF).
  • To assess infant growth parameters and stool patterns in a randomized controlled trial.

Main Methods:

  • A masked, randomized, parallel growth study.
  • Infants (0-9 days old) were fed either AF or HF until 112 days of age.
  • Evaluated growth (weight, length, head circumference), formula intake, stool patterns, and serum albumin.

Main Results:

  • No significant differences in weight, length, head circumference, or formula intake between AF and HF groups.
  • Infants fed HF had more formed stools and a higher mean daily stool count at 14 and 28 days.
  • Serum albumin concentrations were comparable and within normal ranges for both groups.

Conclusions:

  • Amino acid-based formula (AF) supports normal infant growth comparable to extensively hydrolyzed formula (HF).
  • AF is a viable option for infant nutrition, demonstrating similar growth outcomes to hydrolyzed formulas.
  • Both formulas appear to be well-tolerated, supporting healthy development in early infancy.

Keywords:
elemental formulaformulafree amino acid–based formulahydrolysate formulahypoallergenicinfant feedinginfant growthweight

More Related Videos

Probiotic Studies in Neonatal Mice Using Gavage10:36

Probiotic Studies in Neonatal Mice Using Gavage

Published on: January 27, 2019

Individualized Reconstitution of Human Milk Microbiota: A Feasible Approach in Real-World Settings04:16

Individualized Reconstitution of Human Milk Microbiota: A Feasible Approach in Real-World Settings

Published on: February 7, 2025

Related Concept Videos

Development of Human Microbiota01:30

Development of Human Microbiota

The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
Parentral Nutrition: Centeral and Peripheral Parental Nutrition01:27

Parentral Nutrition: Centeral and Peripheral Parental Nutrition

Parenteral Nutrition (PN) delivers essential nutrients directly into the bloodstream, bypassing the digestive system. It is commonly used for individuals with severe digestive disorders or conditions that prevent normal nutrient absorption.
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Oxygen Requirements and Growth Patterns01:29

Oxygen Requirements and Growth Patterns

Microorganisms exhibit diverse oxygen requirements and growth patterns driven by their metabolic strategies and environmental adaptations. Oxygen, while essential for many organisms, can also be toxic under certain conditions, shaping how microorganisms grow and survive.Oxygen Requirements of MicroorganismsMicroorganisms are classified based on their ability to use or tolerate oxygen:● Obligate aerobes like Mycobacterium tuberculosis need oxygen for energy production, as it serves as the...