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Cancer Stem Cells and Tumor Maintenance

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

Cancer Stem Cells and Tumor Maintenance

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Multipotency of Hematopoietic Stem Cells

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

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Related Experiment Video

Updated: May 10, 2026

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

Leukemia stem cells: Old concepts and new perspectives.

Samanta A Mariani¹, Bruno Calabretta¹

¹Department of Cancer Biology and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, United States.

Molecular Aspects of Medicine

|July 4, 2013

Summary

Myeloid leukemias arise from leukemia-initiating cells. Recent studies reveal these leukemia stem cells are more adaptable than previously understood, impacting treatment strategies for myeloid malignancies.

Keywords:

Leukemia Oncogene Stem cell Therapy

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Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

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Identification of Quiescent Cells in a Zebrafish T-Cell Acute Lymphoblastic Leukemia Model Using Cell Proliferation Staining

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Published on: July 19, 2024

Area of Science:

Hematology
Cancer Biology
Stem Cell Biology

Background:

Myeloid leukemias exhibit significant heterogeneity.
This heterogeneity is linked to mutations in leukemia-initiating cells.
The leukemia stem cell model explains leukemia initiation and maintenance.

Purpose of the Study:

To discuss the evolution of the leukemia stem cell model.
To explore the impact of this model on myeloid malignancy therapy.

Main Methods:

Xenotransplantation studies in immunodeficient mice.
Analysis of leukemia-initiating cell immunophenotype and behavior.

Main Results:

The leukemia stem cell model has been validated by numerous studies.
Recent data suggest greater heterogeneity and plasticity of leukemia stem cells.
Leukemia stem cell behavior is influenced by the host microenvironment.

Conclusions:

The leukemia stem cell model provides a framework for understanding myeloid leukemias.
Emerging evidence highlights the dynamic nature of leukemia stem cells.
Understanding leukemia stem cell plasticity is crucial for developing novel therapeutic approaches for myeloid malignancies.