Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dosage Interval and Administration Route: Determination Methods01:19

Dosage Interval and Administration Route: Determination Methods

A medication’s effectiveness largely depends on its appropriate dosage and the route of administration. Dosage ensures that a sufficient drug concentration is maintained in the bloodstream to elicit the desired therapeutic effect without causing toxicity. The route of administration affects the drug's bioavailability, rate of absorption, and onset of action, which are crucial for achieving optimal therapeutic outcomes. Drug dosage calculations are critical to tailoring therapy to individual...
Therapeutic Drug Monitoring: Overview and Classification01:16

Therapeutic Drug Monitoring: Overview and Classification

Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood at designated intervals to ensure the drug concentration stays within a therapeutic range. This monitoring is crucial for optimizing individual dosage regimens, enhancing therapeutic efficacy, and minimizing drug-related toxicity. TDM is vital for drugs with narrow therapeutic windows, significant variability in pharmacokinetics, and a clear correlation between plasma levels and...
Therapeutic Drug Monitoring: Drug Analysis Methods01:26

Therapeutic Drug Monitoring: Drug Analysis Methods

Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood or body tissues to tailor drug therapy effectively. This monitoring is critical for managing drugs with narrow therapeutic indices like digoxin and phenytoin, ensuring they are both safe and effective. For instance, monitoring theophylline levels in asthma patients involves precision and sensitivity to adjust doses according to individual responses to therapy, ensuring efficacy and...
Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions01:24

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multicenter validation of an artificial intelligence-enabled ECG model to predict 1-year risk of atrial fibrillation or flutter.

Heart rhythm·2026
Same author

Mechanistic model of phase-transitioning therapeutics injected into poroelastic tissue for improved targeting of superficial tumors.

Scientific reports·2026
Same author

Mechanistic model of phase-transitioning therapeutics injected into poroelastic tissue for improved targeting of superficial tumors.

Research square·2025
Same author

Development and validation of a novel machine learning-based algorithm to predict incident atrial fibrillation: A multicohort analysis.

Heart rhythm·2025
Same author

Adaptive Machine Learning as Research: Does the Cure Fit the Disease?

The American journal of bioethics : AJOB·2024
Same author

Development and validation of a machine learning-based approach to identify high-risk diabetic cardiomyopathy phenotype.

European journal of heart failure·2024

Related Experiment Video

Updated: May 10, 2026

Fentanyl Analog Screening using LC-TIMS-TOF MS/MS
10:13

Fentanyl Analog Screening using LC-TIMS-TOF MS/MS

Published on: November 8, 2024

QTc interval screening in an opioid treatment program.

David F Katz1, Jun Sun, Vaishali Khatri

  • 1Division of Cardiology, University of Colorado School of Medicine, Aurora, Colorado.

The American Journal of Cardiology
|July 4, 2013
PubMed
Summary

An electrocardiography (ECG)-based cardiac safety program effectively reduced the QTc interval in methadone maintenance patients at high risk for Torsade de pointes. This intervention proved more effective than clinical assessment alone for identifying patients needing ECG screening.

More Related Videos

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
10:17

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence
09:54

Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence

Published on: March 8, 2020

Related Experiment Videos

Last Updated: May 10, 2026

Fentanyl Analog Screening using LC-TIMS-TOF MS/MS
10:13

Fentanyl Analog Screening using LC-TIMS-TOF MS/MS

Published on: November 8, 2024

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
10:17

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence
09:54

Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence

Published on: March 8, 2020

Area of Science:

  • Cardiology
  • Pharmacology
  • Public Health

Background:

  • Methadone is a crucial treatment for opioid dependency.
  • Methadone use is associated with a risk of Torsade de pointes, a potentially fatal arrhythmia.
  • Current methods for identifying at-risk patients are insufficient.

Purpose of the Study:

  • To evaluate an electrocardiography (ECG)-based cardiac safety program for methadone maintenance patients.
  • To assess the effectiveness of ECG-guided intervention in managing QTc interval prolongation.
  • To identify predictors of QTc interval changes in patients receiving methadone.

Main Methods:

  • A prospective evaluation of an ECG-based cardiac safety program in a US opioid treatment program.
  • Assessment of time to follow-up ECG and proportion of patients with QTc interval >500 ms.
  • Mixed-effects modeling to analyze multivariate predictors of QTc interval change.

Main Results:

  • Of 531 new entrants, 82% had at least one ECG; 35% had a pretreatment ECG.
  • In 21 patients with QTc >500 ms, the mean QTc interval significantly decreased by 55.5 ms after intervention.
  • Methadone dose and pretreatment QTc interval were significant predictors of QTc interval change.

Conclusions:

  • An ECG-based intervention can effectively decrease QTc interval prolongation in high-risk methadone patients.
  • Clinical characteristics alone are inadequate for identifying patients requiring ECG screening.
  • Implementation of ECG monitoring is recommended for methadone maintenance programs.