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Imidafenacin on bladder and cognitive function in neurologic OAB patients
Ryuji Sakakibara1, Fuyuki Tateno, Masashi Yano
1Department of Neurology and Internal Medicine, Sakura Medical Center, Toho University, 564-1 Shimoshizu, Sakura, 285-8741, Japan. sakakibara@sakura.med.toho-u.ac.jp
Summary
Imidafenacin improved bladder symptoms in neurologic overactive bladder (OAB) patients without negatively impacting cognitive function. This study suggests imidafenacin is a safe treatment option for OAB patients with underlying neurologic conditions.
Area of Science:
- Neurology
- Urology
- Pharmacology
Background:
- Neurologic diseases can cause overactive bladder (OAB), leading to significant urinary symptoms and reduced quality of life.
- Current treatments for OAB may have side effects, particularly concerning cognitive function in elderly patients.
Purpose of the Study:
- To investigate the efficacy of imidafenacin, an anticholinergic agent, on bladder function and cognitive performance in patients with neurologic OAB.
- To assess the safety profile of imidafenacin concerning cognitive function in this patient population.
Main Methods:
- A study involving 62 patients with neurologic OAB who received imidafenacin 0.2 mg/day for 3 months.
- Evaluations included urinary symptom surveys, cognitive tests (MMSE, FAB, ADAS-cog), urodynamics, and near-infrared spectroscopy (NIRS) in a subset of patients.
- Data were collected before and after treatment to assess changes in bladder and brain function.
Main Results:
- Imidafenacin significantly improved key OAB symptoms such as urgency and nighttime frequency, alongside enhancing the quality of life index (p < 0.05).
- Urodynamic studies indicated an increase in bladder capacity (p < 0.05), though detrusor overactivity did not show significant changes.
- Cognitive measures did not demonstrate significant changes, and NIRS suggested a trend towards prefrontal activation without statistical significance.
Conclusions:
- Imidafenacin effectively ameliorates bladder sensations in patients with neurologic OAB without causing cognitive decline.
- The findings support the safety of imidafenacin for treating OAB in patients with neurologic conditions, with a potential trend towards improved prefrontal brain activity.
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