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Comparatively preserved impulse control in late-onset opiate users.

F Passetti1, A Verdejo-Garcia, M Abou-Saleh

  • 1Division of Mental Health, St George's University of London, London, UK, fmp20@cam.ac.uk.

Psychopharmacology
|July 4, 2013
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Summary

Late-onset opiate addiction is linked to less impulsive decision-making. This suggests distinct subgroups within opiate addiction, differing in problem onset and impulsivity.

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Area of Science:

  • Neuroscience
  • Psychology
  • Addiction Research

Background:

  • Impulsive decision-making is common in early-onset alcohol addiction.
  • The relationship between onset age and decision-making in opiate addiction is not well understood.
  • Understanding this link has significant theoretical and clinical implications for opiate addiction.

Purpose of the Study:

  • To investigate the association between the age of onset of addictive behaviors and decision-making.
  • To explore decision-making differences in opiate-dependent individuals based on their onset age.

Main Methods:

  • Ninety-three treatment-seeking opiate-dependent individuals were categorized into early, intermediate, and late onset groups.
  • Participants completed impulsivity questionnaires.
  • Delay discounting and gambling tasks were administered to assess decision-making.

Main Results:

  • Late-onset opiate users (≥25 years) exhibited lower delay discounting rates compared to early (<18 years) and intermediate onset groups.
  • No significant differences were observed in gambling task performance across groups.
  • Late-onset individuals were older with shorter drug histories, but age/duration did not correlate with delay discounting.

Conclusions:

  • Findings suggest at least two distinct subgroups of opiate-dependent individuals exist.
  • These subgroups are characterized by different problem onset ages and varying propensities for impulsive behavior.
  • Distinct underlying mechanisms may contribute to addiction in these subgroups.