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Related Experiment Video

Updated: May 10, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Published on: August 13, 2019

Progestin-only contraceptives: effects on weight.

Laureen M Lopez¹, Alison Edelman, Mario Chen

¹Clinical Sciences, FHI 360, Research Triangle Park, North Carolina, USA. llopez@fhi360.org.

The Cochrane Database of Systematic Reviews

|July 4, 2013

Summary

This summary is machine-generated.

Progestin-only contraceptives (POCs) show limited evidence of significant weight gain, with mean gains typically under 2 kg. However, some studies indicate increased body fat and decreased lean mass compared to non-hormonal methods.

Related Experiment Videos

Last Updated: May 10, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Published on: August 13, 2019

Area of Science:

Reproductive Health
Endocrinology
Pharmacology

Background:

Progestin-only contraceptives (POCs) are suitable alternatives for individuals who cannot use estrogen-containing methods.
POCs offer long-acting, cost-effective pregnancy prevention, but concerns about weight gain can impact user initiation and adherence.

Purpose of the Study:

To evaluate the association between the use of progestin-only contraceptives and changes in body weight.

Main Methods:

A systematic review of comparative studies was conducted, searching multiple databases including MEDLINE, CENTRAL, and POPLINE up to May 2013.
Studies examining POCs against other contraceptive methods or no contraception were included, with primary outcomes being mean change in body weight or composition.

Main Results:

Most studies (12/16) found no significant weight change differences between POC users and controls.
However, three studies indicated greater weight gain with specific POCs (depot medroxyprogesterone acetate and implant) compared to non-hormonal methods.
Two studies assessing body composition revealed increased body fat and decreased lean body mass in POC users versus non-hormonal contraceptive users.

Conclusions:

Evidence quality for POC-associated weight change is moderate to low.
While significant weight gain is not consistently observed, counseling on potential body composition changes may improve contraceptive continuation.