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Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

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Related Experiment Video

Updated: May 10, 2026

Orthotopic Left Lung Transplantation in Rats

Orthotopic Left Lung Transplantation in Rats

Published on: July 3, 2025

Lung transplantation for obstructive lung diseases.

Rupal J Shah¹, Robert M Kotloff

¹Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA.

Seminars in Respiratory and Critical Care Medicine

|July 4, 2013

Summary

Lung transplantation is a common treatment for Chronic Obstructive Pulmonary Disease (COPD), but optimal timing and outcomes require further study. This review explores transplantation for COPD and rarer obstructive lung diseases.

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Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

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Last Updated: May 10, 2026

Orthotopic Left Lung Transplantation in Rats

Orthotopic Left Lung Transplantation in Rats

Published on: July 3, 2025

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

Area of Science:

Pulmonology
Thoracic Surgery
Transplantation Medicine

Background:

Chronic Obstructive Pulmonary Disease (COPD) is a leading reason for lung transplantation, comprising about one-third of global procedures.
While common, optimal timing, surgical approach, and survival benefits for COPD lung transplantation are still debated.
Other obstructive lung disorders like alpha-1-antitrypsin deficiency emphysema, lymphangioleiomyomatosis, and Langerhans cell histiocytosis are less frequent indications for this procedure.

Purpose of the Study:

To explore critical questions surrounding lung transplantation for COPD.
To examine the application and challenges of lung transplantation for rare obstructive lung disorders.

Main Methods:

Review of existing literature and clinical experience regarding lung transplantation for obstructive lung diseases.
Analysis of outcomes, timing, and procedural considerations.

Main Results:

Lung transplantation is a significant intervention for COPD, yet specific aspects of its application remain subjects of ongoing research and clinical discussion.
Transplantation for rarer obstructive conditions also presents unique challenges and unanswered questions.

Conclusions:

Further research is needed to refine the timing and techniques for lung transplantation in COPD to maximize survival benefits.
Understanding the complexities of lung transplantation for uncommon obstructive lung diseases is crucial for improving patient care.