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Updated: Jul 28, 2026

Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet
Published on: November 4, 2015
Fatal pulmonary thromboembolism after successful transsphenoidal hypophysectomy for Cushing's disease
J A Jackson1, A Trowbridge, M Smigiel
1Department of Medicine, Scott and White Clinic, Scott and White Memorial Hospital, Temple, TX 76508.
Abstract:
We have reported the case of a 30-year-old woman with Cushing's disease who died of massive pulmonary thromboembolism 5 weeks after successful transsphenoidal hypophysectomy. Glucocorticoid excess appears to cause a hypercoagulable state, and consideration of this thromboembolic propensity and its potential duration after cure is indicated in all patients with Cushing's syndrome during the perioperative period. At the present time, we recommend the routine perioperative use of intermittent pneumatic compression in all patients with Cushing's disease or Cushing's syndrome.
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