Chlorprothixene in bodies after exhumation
Herbert Käferstein1, Guido Sticht, Burkhard Madea
1Institute of Forensic Medicine, University of Cologne, Melatengürtel 60-62, D-50823 Köln, Germany.
Abstract:
Toxicological analyses on body tissues and interpretation of results after exhumation are a challenging task. We report five cases in which toxicological analyses had to be performed due to suspicion of homicide by chlorprothixene intoxication. Exhumations had to be carried out following post mortem intervals in earth graves between two and five and a half years. Chlorprothixene and in some cases also its metabolites could be detected in liver and brain. For the interpretation of the results, chlorprothixene concentrations determined in brain should be used because of a relative isolation of the brain within the skull. However, a loss of organ weights due to post mortem degradation, which may lead to an increase of drug levels, should be taken into account.
Related Concept Videos
Drug Distribution: Tissue Binding
For...
Prevention of Further Absorption of Poison
Pharmaceutical Poisoning: Treatment Strategies
Enhanced Elimination of Poison
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
Anticholinesterase Agents: Poisoning and Treatment
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is slower than the...
Toxidromes: Clinical Features


