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Age-dependent differences in diabetes and acute hyperglycemia between men and women with ST-elevation myocardial

Amber M Otten1, Jan Paul Ottervanger, Jorik R Timmer

  • 1Isala klinieken, Department of Cardiology, Groot Wezenland 20, Zwolle 8011 JW, The Netherlands. v.r.c.derks@isala.nl.

Diabetology & Metabolic Syndrome
|July 5, 2013
PubMed

Insights

In ST-elevation myocardial infarction (STEMI) patients, diabetes and hyperglycemia are more prevalent in older women than men. These age-dependent differences in diabetes and hyperglycemia impact prognosis and require further investigation for optimal treatment.

Area of Science:

  • Cardiology
  • Endocrinology
  • Geriatrics

Background:

  • Acute hyperglycemia and diabetes impair prognosis in ST-elevation myocardial infarction (STEMI) patients.
  • Prevalence differences in diabetes and hyperglycemia between men and women in STEMI patients across age groups are not well-understood.

Purpose of the Study:

  • To investigate age-specific differences in the prevalence of diabetes and acute hyperglycemia between men and women with STEMI.
  • To analyze the association of these conditions with one-year mortality in different demographic groups.

Main Methods:

  • A cohort of 4640 STEMI patients undergoing primary PCI between 2004-2010 was analyzed.
  • Patients were stratified by age (<65 and ≥65 years) and sex.
  • Diabetes was defined by prior diagnosis or admission HbA1c; hyperglycemia was assessed by admission glucose levels.

Main Results:

  • In older STEMI patients (≥65 years), diabetes was more prevalent in women (25% vs 17%) and admission glucose was higher (8.7 vs 8.4 mmol/l).
  • In younger patients (<65 years), prevalence and glucose levels were comparable between sexes.
  • Increased admission glucose was associated with higher one-year mortality in older women (OR 1.3, 95% CI 1.1-1.7).

Conclusions:

  • Sex differences in diabetes and hyperglycemia prevalence among STEMI patients are age-dependent, primarily observed in older individuals.
  • These findings suggest potential implications for tailored medical treatment strategies in older male and female STEMI patients.
  • Further research is warranted to explore these age- and sex-specific differences and their clinical impact.
Abstract

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