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Updated: May 10, 2026

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model

Published on: September 3, 2020

Cell therapy for cardiovascular regeneration.

Naofumi Takehara¹

¹Department of Cardiovascular Regeneration and Innovation, Asahikawa Medical University, Hokkaido, Japan.

Annals of Vascular Diseases

|July 5, 2013

Summary

Cardiac regeneration therapy faces challenges due to transient effects from current cell therapies. Future research must refine targets, materials, and methods, including induced pluripotent stem cells (iPSCs), for improved cardiovascular regeneration.

Keywords:

cardiovascular disease cell therapy cytokine regeneration stem/progenitor cell

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Area of Science:

Regenerative Medicine
Cardiovascular Biology
Biotechnology

Background:

Cardiovascular diseases (CVDs) result in poor patient outcomes globally.
The postnatal heart, a terminally differentiated organ, presents challenges for regeneration.
Current cell-based therapies for cardiac repair show transient effects, necessitating improved strategies.

Purpose of the Study:

To review advances in cardiovascular regeneration therapy.
To discuss the redevelopment of cell-based cardiac regeneration strategies.
To explore the potential of induced pluripotent stem cells (iPSCs) and tissue engineering.

Main Methods:

Review of ongoing clinical trials in cardiac regeneration.
Analysis of basic research in cardiovascular regeneration.
Evaluation of tissue engineering technologies for cardiac repair.

Main Results:

Clinical trials using standard cell types have yielded only temporary benefits.
Induced pluripotent stem cells (iPSCs) offer innovative potential for cardiac regeneration.
Direct conversion of somatic cells to cardiomyocytes bypasses the need for pluripotency.

Conclusions:

Rethinking cell-based cardiovascular regeneration is crucial, focusing on precise targets, materials, and methodologies.
Induced pluripotent stem cells (iPSCs) and direct reprogramming represent significant advancements.
Tissue engineering holds promise for future cardiac repair and reorganization strategies.