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Reduced Ventricular Arrhythmogeneity and Increased Electrical Complexity in Normal Exercised Rats.

Horesh Dor-Haim1, Omer Berenfeld, Michal Horowitz

  • 1Heart Institute, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

Plos One
|July 5, 2013
PubMed
Summary

Aerobic training enhances heart resistance to ventricular fibrillation (VF) by inducing intrinsic cardiac remodeling. This study in rats shows exercise reduces VF occurrence and duration, improving cardiac electrical stability.

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Area of Science:

  • Cardiovascular Physiology
  • Exercise Science
  • Cardiac Electrophysiology

Background:

  • Mechanisms of aerobic training's protective effect against sudden cardiac death are unclear.
  • Hypothesis: Exercise-induced resistance to ventricular tachycardia and fibrillation (VT/VF) involves intrinsic cardiac remodeling.

Purpose of the Study:

  • To investigate the effects of short-term and long-term aerobic training on VT/VF inducibility in rats.
  • To determine if exercise leads to intrinsic cardiac remodeling that enhances resistance to VF.

Main Methods:

  • Rats underwent 4-week (ST) or 8-week (LT) aerobic training, or remained sedentary (CTRL).
  • Hearts were isolated and perfused; VT/VF inducibility was assessed using S1-S2 pacing.
  • ECG time-series were analyzed using Fast Fourier Transforms to assess heart rate variability and spectral characteristics.

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Main Results:

  • Training increased aerobic capacity and heart-to-body weight ratio.
  • VF probability and duration significantly decreased in ST and LT groups compared to CTRL.
  • Pacing current required for VF induction increased, and ECG spectral analysis showed a shift towards broader, faster frequency components.

Conclusions:

  • Aerobic exercise in rats reduces susceptibility to VF.
  • This protective effect is associated with intrinsic cardiac remodeling.
  • Remodeling involves changes in ECG spectral characteristics, indicating enhanced cardiac electrical stability.