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Tracing evolutionary footprints to identify novel gene functional linkages

Yong Chen1, Li Yang, Yunfeng Ding

  • 1National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. yongchen@tsinghua.edu.cn

Plos One
|July 5, 2013
PubMed
Summary

We developed TRACE, a computational method to identify gene functional linkages in prokaryotes by analyzing evolutionary information across 341 genomes. TRACE successfully predicted gene functions and identified novel proteins, including a chromosome partitioning protein.

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