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Related Experiment Video

Updated: May 10, 2026

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
05:46

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

Unusual orange-colored choroidal metastases.

Hatem Krema1, Hugh McGowan, Herbert Tanzer

  • 1Departments of Ocular & Radiation Oncology, Princess Margaret Cancer Center, University of Toronto, Toronto, ON, Canada.

Journal of Ophthalmic & Vision Research
|July 5, 2013
PubMed
Summary

Orange choroidal metastases from rare cancers like small cell neuroendocrine tumors and alveolar soft part sarcoma were identified. This finding aids in diagnosing occult primary tumors and differentiating from hemangiomas using angiography.

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Area of Science:

  • Ophthalmology
  • Oncology
  • Pathology

Background:

  • Choroidal metastases can present with varied clinical features.
  • Orange-colored choroidal lesions are uncommon and require careful diagnosis.
  • Primary cancers are not always obvious when metastases are detected.

Observation:

  • Two patients presented with orange-colored choroidal lesions.
  • One patient had metastatic small cell neuroendocrine tumor (SCNET) of the larynx and oropharynx.
  • The other patient had metastatic alveolar soft part sarcoma (ASPS) of the leg.

Findings:

  • Ultrasonography showed choroidal masses similar to hemangiomas.
  • Fluorescein angiography revealed delayed initial and minimal subsequent fluorescence.
  • This pattern distinguished the metastases from circumscribed choroidal hemangiomas.
Keywords:
ColorEyeMetastasisNeuroendocrineOrangeSarcoma

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Last Updated: May 10, 2026

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
05:46

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Published on: December 2, 2022

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
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Implications:

  • SCNET and ASPS should be considered in the differential diagnosis of orange choroidal metastases.
  • Identifying these lesions can help locate occult primary tumors.
  • Fluorescein angiography is crucial for differentiating these metastases from choroidal hemangiomas.