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Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance
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Helicobacter pylori infection and pediatric asthma

Abdullah Karimi1, Koroush Fakhimi-Derakhshan, Farid Imanzadeh

  • 1Pediatric Infections Disease Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Iranian Journal of Microbiology
|July 5, 2013
PubMed

Insights

Helicobacter pylori infection was not significantly linked to childhood asthma in this study. However, H. pylori showed an association with older age and longer asthma duration in affected children.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Respiratory Medicine

Background:

  • Childhood asthma is a significant health concern.
  • Environmental factors, including infectious diseases, are implicated in asthma development.
  • Helicobacter pylori (H. pylori) infection is prevalent and its role in childhood asthma requires investigation.

Purpose of the Study:

  • To investigate the association between H. pylori infection and childhood asthma.
  • To compare H. pylori prevalence in asthmatic children versus healthy controls.

Main Methods:

  • A cross-sectional study involving 196 children (6-12 years old).
  • 98 children with asthma (cases) and 98 healthy children (controls).
  • Urea breath test used to detect H. pylori infection in all participants.

Main Results:

  • H. pylori infection prevalence did not differ significantly between asthmatic (18.36%) and healthy (23.36%) children (p=0.380).
  • In asthmatic children, H. pylori infection was significantly associated with older age (p<0.001) and longer asthma duration (p=0.010).
  • No significant correlation found between H. pylori and sex, asthma severity, control status, or pulmonary function tests in asthmatic children.

Conclusions:

  • H. pylori infection is not significantly associated with childhood asthma.
  • In asthmatic children, H. pylori infection is linked to increased age and disease duration.
  • Further research may explore the complex interplay between H. pylori and asthma.
Abstract

Keywords:
Helicobacter pyloriasthmaurea breath test

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