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Updated: May 10, 2026

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Retinal nerve fiber layer thickness. The Beijing Eye Study 2011.

Ya Xing Wang1, Zhe Pan, Liang Zhao

  • 1Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China.

Plos One
|July 5, 2013
PubMed
Summary

Retinal nerve fiber layer (RNFL) thickness is greatest in the inferior and superior sectors, decreasing with age and axial length. Key factors influencing RNFL thickness include age, neuroretinal rim area, axial length, and gender.

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Area of Science:

  • Ophthalmology
  • Optometry
  • Retinal Imaging

Background:

  • Retinal nerve fiber layer (RNFL) thickness is a crucial indicator of optic nerve health.
  • Population-based studies are essential for establishing normative RNFL values.
  • Understanding factors influencing RNFL thickness aids in early disease detection.

Purpose of the Study:

  • To measure RNFL thickness in a population-based setting.
  • To identify factors associated with RNFL thickness variations.
  • To characterize the RNFL profile in a Chinese population.

Main Methods:

  • The Beijing Eye Study 2011 included 3468 participants.
  • RNFL thickness was measured using spectral domain optical coherence tomography (SD-OCT) in 1654 individuals.

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  • Multivariate analysis was employed to assess influencing factors.

    • Main Results:

    • RNFL thickness exhibited a 'double hump' pattern, with the inferior sector being thickest, followed by superior, temporal, and nasal sectors.
    • Global RNFL thickness was associated with younger age, larger neuroretinal rim area, shorter axial length, thicker subfoveal choroidal thickness, larger optic disc area, less refractive lens power, flatter anterior cornea, and female gender.
    • In individuals aged 50+, RNFL thickness declined by approximately 0.3% per year and decreased by 2.4 µm per mm of axial elongation.

    Conclusions:

    • The RNFL exhibits a distinct sectoral thickness distribution.
    • Several ocular and demographic factors significantly influence global RNFL thickness.
    • Age-related RNFL decline and changes with axial elongation provide valuable normative data for clinical interpretation.