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Related Experiment Videos

Ultrasonic clot disruption: an in vitro study.

A S Hong1, J S Chae, S B Dubin

  • 1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048-0750.

American Heart Journal
|August 1, 1990
PubMed
Summary

Ultrasound effectively disrupts human blood clots in vitro, with disruption time increasing with probe length but remaining under three minutes. Clot age did not impact disruption, and ultrasound offers a mechanical alternative to fibrinolysis.

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Area of Science:

  • Biomedical Engineering
  • Thrombosis Research
  • Medical Ultrasound

Background:

  • Blood clots pose significant clinical challenges, necessitating effective dissolution methods.
  • Current treatments like fibrinolysis have limitations and risks.
  • Ultrasound presents a potential mechanical approach for clot disruption.

Purpose of the Study:

  • To evaluate the in vitro efficacy of ultrasound for human blood clot disruption.
  • To investigate the influence of clot age, probe length, and streptokinase on ultrasound efficacy.
  • To characterize the size distribution of particulate debris generated by ultrasound.

Main Methods:

  • In vitro study of human blood clot disruption using ultrasound.
  • Variable parameters included clot age (1-7 days), wire probe length (31-105 cm), and addition of streptokinase.

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  • Particulate debris sizing was performed using the resistive-pulse technique.

    • Main Results:

    • Ultrasound effectively disrupted blood clots within 3 minutes, regardless of clot age.
    • Disruption time correlated with the square of probe length.
    • Whole blood clots produced significantly more and larger debris (up to 80 microns) than cell-free fibrin clots.
    • Streptokinase had minimal impact on debris size distribution.

    Conclusions:

    • Ultrasound is a viable method for in vitro human blood clot disruption.
    • Mechanical and cavitational effects of ultrasound are key mechanisms, independent of fibrinolysis.
    • Further research may explore ultrasound's therapeutic potential in managing thrombotic events.