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Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

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Related Experiment Video

Updated: May 10, 2026

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy
11:51

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy

Published on: March 1, 2016

Cardiovascular repair with bone marrow-derived cells.

Woan-Sang Kim1, Sangho Lee, Young-Sup Yoon

  • 1Division of Cardiology, Department of Medicine, Emory University School of Medicine, GA, USA.

Blood Research
|July 5, 2013
PubMed
Summary

Recent studies reveal bone marrow (BM)-derived cells

Area of Science:

  • Regenerative Medicine
  • Cell Therapy
  • Cardiovascular Research

Background:

  • Pre-clinical studies of bone marrow (BM)-derived cells show promise, but clinical trials yield inconsistent results.
  • Recent findings indicate humoral and paracrine effects, not cell transdifferentiation, drive tissue regeneration.
  • Understanding BM-derived cell mechanisms is crucial for improving therapeutic potential.

Purpose of the Study:

  • To discuss advancements in BM-derived cell therapy.
  • To highlight the therapeutic potential of newly discovered CD31(+) cells.
  • To explore efficient methods for isolating potent cell populations.

Main Methods:

  • Review of recent scientific literature on BM-derived cell therapy.
  • Analysis of studies investigating CD31(+) cell properties.
Keywords:
Bone marrowCD31Cardiovascular repairCell therapyNeovascularizationParacrine

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Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting
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Last Updated: May 10, 2026

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  • Discussion of neovascularization mechanisms in ischemic tissues.

    • Main Results:

    • Humoral and paracrine effects are key to tissue regeneration, not cell transdifferentiation.
    • Hematopoietic CD31(+) cells possess angiogenic and vasculogenic activities.
    • CD31(+) cells show significant potential for therapeutic neovascularization.

    Conclusions:

    • BM-derived cell therapy's efficacy relies on paracrine factors.
    • CD31(+) cells represent a promising cell population for regenerative medicine.
    • Further research into CD31(+) cells can optimize therapeutic strategies for ischemic conditions.