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Updated: Feb 24, 2026

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
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Nitrite in organ protection

Tienush Rassaf1, Peter Ferdinandy, Rainer Schulz

  • 1Department of Medicine, Division of Cardiology, Pulmonary and Vascular Medicine, University Hospital Düsseldorf, Düsseldorf, Germany.

British Journal of Pharmacology
|July 6, 2013
PubMed

Insights

The nitrate-nitrite-nitric oxide pathway is therapeutically important. Modulating these levels offers new cytoprotective strategies and potential for organ protection.

Area of Science:

  • Biochemistry
  • Physiology
  • Pharmacology

Background:

  • The nitrate-nitrite-nitric oxide (NO) pathway has gained significant therapeutic interest.
  • Nitrate and nitrite levels can be modulated to influence NO signaling.
  • This pathway is crucial for various physiological processes.

Purpose of the Study:

  • To summarize current literature on the nitrate-nitrite-nitric oxide pathway.
  • To provide an overview of nitrite's potential in organ protection.
  • To highlight novel cytoprotective strategies.

Main Methods:

  • Literature review and synthesis.
  • Analysis of existing research on NO pathway modulation.
  • Evaluation of studies on nitrite's role in organ protection.

Main Results:

  • The nitrate-nitrite-nitric oxide pathway is a key area in therapeutic research.
  • Modulation of nitrate and nitrite levels impacts S-nitros(yl)ation.
  • Nitrite shows promise as a therapeutic agent for organ protection.

Conclusions:

  • The NO pathway presents novel opportunities for cytoprotective therapies.
  • Targeting nitrate and nitrite levels is a viable strategy for organ protection.
  • Further research into nitrite's therapeutic applications is warranted.
Keywords:
nitric oxidenitrite

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