Related Experiment Video
Updated: May 10, 2026

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
Capillary zone electrophoresis for separation and quantitative determination of mexiletine and its main phase I
Claudio Bruno, Maria Maddalena Cavalluzzi, Alessia Carocci
1Dipartimento di Farmacia- Scienze del Farmaco, Università degli Studi di Bari "Aldo Moro", via Orabona 4, 70126 Bari, Italy. alessia.catalano@uniba.it.
Abstract:
The simultaneous separation and quantification of the analytes within the minimum analysis time and the maximum resolution and efficiency are the main objectives in the development of a capillary electrophoretic method for the determination of solutes. In this paper we describe a specific, sensitive and robust method, using capillary zone electrophoresis with internal standard and UV detection, for the separation and quantification of the anti-arrhythmic drug mexiletine, its main phase I metabolites, and its main nitrogenous degradation product.
More Related Videos
07:46Sheathless Capillary Electrophoresis–Mass Spectrometry for Metabolic Profiling of Biological Samples
Published on: October 1, 2016
08:56Detection of Regulated Ergot Alkaloids in Food Matrices by Liquid Chromatography-Trapped Ion Mobility Spectrometry-Time-of-Flight Mass Spectrometry
Published on: November 22, 2024
Related Concept Videos
Capillary Electrophoresis: Applications
Capillary zone electrophoresis (CZE) separates ionic components based on their electrophoretic mobility. It has been used to separate proteins, amino acids,...
Electrophoresis: Overview
There...
Ion-Exchange Chromatography
Capillary Electrophoresis: Instrumentation