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Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
Published on: February 14, 2018
Antifungal activity of 3-(heteroaryl-2-ylmethyl)thiazolidinone derivatives
Gabriela H Marques, Alice Kunzler, Valéria D O Bareño
1Universidade Federal de Pelotas, CCQFA, R. Gomes Carneiro 1, caixa postal 354, CEP: 96001-970, Brazil. wjcunico@yahoo.com.br.
Abstract:
Thiazolidinones, synthesized from multicomponent reactions of 2-heteroarylmethylamine, arenealdehydes and mercaptoacetic acid, have been tested against six yeasts, namely Candida albicans, C. parapsilosis, C. guilliermondii, Cryptococcus laurentii, Trichosporon asahii and Rhodotorula spp. The activities were expressed as minimum inhibitory concentrations (MIC) and the minimum fungicidal concentrations (MFC). The most affected yeasts were Rhodotorula spp and T. asahii. The cytotoxicities of the thiazolidinones against the fibroblast 3T3/NIH cell line are also described. The antifungal results and the low cytotoxicity of the compounds in this work provide good guides for the further development of active compounds.
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