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Bioinformatics analysis of breast cancer bone metastasis related gene-CXCR4
Heng-Wei Zhang1, Xian-Fu Sun, Ya-Ning He
1Department of Breast, Henan Cancer Hospital, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, China.
Objective:
To analyze breast cancer bone metastasis related gene-CXCR4.
Methods:
This research screened breast cancer bone metastasis related genes by high-flux gene chip.
Results:
It was found that the expressions of 396 genes were different including 165 up-regulations and 231 down-regulations. The expression of chemokine receptor CXCR4 was obviously up-regulated in the tissue with breast cancer bone metastasis. Compared with the tissue without bone metastasis, there was significant difference, which indicated that CXCR4 played a vital role in breast cancer bone metastasis.
Conclusions:
The bioinformatics analysis of CXCR4 can provide a certain basis for the occurrence and diagnosis of breast cancer bone metastasis, target gene therapy and evaluation of prognosis.
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